CelLock TM: An innovative standardized cell-block preparation procedure

Histology Educational Series In the previous blog we saw that every histology laboratory has a method for preparing paraffin cell-block specimens, and we reviewed those methods.  This review showed that all of these methods display various deficiencies with regard to collecting and preserving the entirety of the patient specimen with optimal retention of all of …

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CellBlockistry – The Time is Now

Histology Educational Series Every histology laboratory has a method for preparing paraffin cell-block specimens.  Certain cytology specimens, fine needle aspirates (FNAs), tiny tissue fragments, fragmented needle core biopsies and suspensions of cells for both clinical and research evaluation all require a method to get the specimen from the specimen container into a paraffin block for …

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Troubleshooting Histology: Double Barrel Style – H&E and Special Stains

Why even bother to learn about troubleshooting? Wouldn’t it be more interesting to listen to one of the presentations on molecular technology? Possibly. But what would you do if your pathologist brought you a slide from the first batch of today’s H&E’s that looked sub-optimal to review alongside an optimal slide stained the previous day? …

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Vaccination Against the Covid-19 Disease – Part 3

Author’s note:  This blog is part of a series on the current status of the Covid-19 vaccination program in the United States.  All information contained herein was obtained from peer reviewed scientific journals and publications as well as legitimate vetted science-based websites.  These sources are referenced such that you may obtain further information from them.  …

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Vaccination Against the Covid-19 Disease – Part 2

Author’s note:  This blog is part of a series on the current status of the Covid-19 vaccination program in the United States.  All information contained herein was obtained from peer reviewed scientific journals and publications as well as legitimate vetted science-based websites.  These sources are referenced such that you may obtain further information from them.  …

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Validating Your New Stainer According to CAP and CLIA Requirements

Congratulations on purchasing a new autostainer! There are three parts to the start-up process:  Instrument Verification, Stain Protocol Optimization, and Validation of the Staining Protocols.  Instrument Verification – see CAP All Common Checklist (06/04/2020) COM.40350 Optimally, the company you purchase the instrument from should provide an operator manual; provide verbal procedural instructions; and test the …

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Part 2: Coronavirus Histopathology Laboratory Precautions

In the short time since part 1 of this series “Coronavirus in Histology” was published, the COVID-19 virus has continued its spread around the globe. Currently, the entire country of Italy is on lock down. The BBC reports (1) that the Italian government has implemented emergency measures related to the coronavirus outbreak, which include a …

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Part 1: Coronavirus in the Histology Laboratory

The current world health care concern over coronavirus (i.e. COVID-19) has generated many questions regarding many aspects of this fast spreading influenza disease. It is important to address the subject of the affect, if any, of this disease on how we work in and operate histopathology laboratories. An important and timely article was published online …

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#7 IHC Double Staining

The DNA of a nucleus directs the actions of the cell by instructing it to manufacture specific proteins.  This “instruction” is sent from the nucleus into the cytoplasm by “messenger RNA” (mRNA).  The mRNA exits the nucleus to bring the “message’” into the cytoplasm, binding with ribosomes to manufacture proteins.  Figure 1 illustrates this principle. …

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Rankin Gives Back to the Community

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Rankin Biomedical donated a variety of laboratory supplies to Lake Fenton High School. From syringes to block heaters and stainless steel instruments, the supplies are being put to great use in Biology, Chemistry and Physics classes!