Leica RM2255 Automated Microtome


The Leica RM2255 Microtome effortlessly transitions between motorized and manual sectioning, guaranteeing the reproducibility of high-quality sections. The intuitive touch control panel enhances user efficiency, while safety and precision harmonize through features like Knife Holder E and an ergonomic handwheel. Abundant storage and optional cooling further enhance its capabilities. Powered by Leica’s proven technology, including a patented gravitational force compensation system and precise micrometer feed, the RM2255 sets new standards. It’s the microtome of choice for laboratories seeking exceptional control, versatility, and safety.


Leica RM2255 Microtome: Setting the Benchmark for Precision and Performance

Pinnacle of Microtomy Excellence

In the realm of rotary microtomes, exceptional performance is non-negotiable. Leica Microsystems, a pioneer in laboratory technology, sets a new benchmark with the fully automated Leica RM2255 microtome, a testament to innovation, ergonomics, safety, efficiency, and economy. This two-in-one marvel effortlessly transitions between motorized and manual sectioning, ensuring reproducible, high-quality sections. It’s a fusion of proven high-performance precision technology and the hallmark features of Leica, the industry leader in microtomy.

Intuitive Touch Control

The control panel redefines ease of use with colored, raised keys that allow for effortless ‘touch’ control. This design innovation lets operators focus entirely on sectioning and retrieval. The panel’s adjustable inclination, compact footprint, and flexible positioning on either side of the instrument enhance user comfort and efficiency.

Safety and Precision in Harmony

The Leica RM2255 boasts the popular Knife Holder E, accommodating both high and low-profile disposable blades while offering comprehensive blade coverage through an integrated finger guard during sectioning. Fewer clamping levers provide unobstructed access to the cutting area, further cleared by the ability to relocate locking pins and reposition levers after locking.

Ample Storage and Cooling Options

For storage convenience, an integrated tray generously accommodates ancillary tools. For those needing cool storage of specimen blocks right on the microtome, an optional cooling tray with unique cooling blocks is available.

Enhanced Handwheel and Safety

The microtome’s handwheel features a safe, smooth-running design with a new ergonomic handle, a traditional lock at any rotation point, and an easily accessible quick-lock mechanism for securing specimens in the uppermost position. The focus on safety is paramount, with Leica ensuring that user well-being is never compromised.

Proven and Reliable Technology

Leica’s patented gravitational force compensation system ensures a smooth and lightweight handwheel operation, particularly beneficial during manual sectioning. A precise micrometer feed system enables sectioning from 0.5 µm to 100 µm, thanks to a stepper motor and low-maintenance cross-roller bearings. The microtome’s powerful sectioning motor is robust enough to handle even hard specimens without causing sectioning artifacts. The specially designed electronics system allows flexible instrument operation while maintaining precise control over specimen advance and cutting speeds. Additionally, the universal knife holder base is compatible with all routine Leica RM2200 series microtome knife holder systems requiring a base, and the one-hand-operated universal cassette clamp simplifies specimen clamping and removal.

Exceptional Control and Versatility

With an extensive section thickness setting range from 0.5 µm to 100 µm, including precise increments, and trimming section thickness settings ranging from 1 µm to 600 µm, the Leica RM2255 offers unparalleled control and versatility. Specimen retraction, both manual and motorized, provides flexibility and can be fine-tuned based on sectioning speed. With a vertical stroke of 70 mm, it accommodates a wide range of specimen sizes and shapes.

The Leica RM2255 Microtome is the epitome of precision, performance, and user-friendliness, embodying Leica’s commitment to pushing the boundaries of microtomy technology while prioritizing the needs and safety of laboratory professionals.

Additional information






Dimensions (W x D x H)

16.3" x 24" x 12"


81 lbs



Operator Manual

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