Leica CM3050 S Research Cryostat

  • Professionally Refurbished, Like-New
  • New Compressor
  • 1-Year Warranty
  • Save 65%

Processing multiple specimen and performing serial cuts can result in high section numbers. Nevertheless, reproducibility can’t be compromised. Permanent attention to detail and many hours in front of the cryostat can be exhausting for the user. The Leica CM3050 S cryostat is designed to help with exactly these time-consuming jobs.

The low working height and available knee space of the Leica CM3050 S cryostat allow the user to work comfortably while sitting. Motorized drive and section counter improve productivity for multiple serial sections.

Particularly when working with delicate specimens, e.g. brain samples, the precise specimen orientation and the specimen feed system provide for reproducible sections.


Leica CM3050 S Research Grade Cryostat

The Leica CM3050 S Cryostat is designed primarily for the demanding needs of cryosectioning systems in the field of biomedical, neuro-anatomical and pharmaceutical research. Particularly when working with delicate specimens – for example brain samples in neuroscience – the precise specimen orientation and the specimen feed system via step motor guarantees reproducible thin serial sections of maximum quality.

The Leica CM3050 S Cryostat features superior user comfort with excellent safety standards for practically all types of cryosectioning applications. It is the instrument of choice for all cryosectioning research applications and also for advanced clinical cryosectioning needs. The Leica CM3050 S Cryostat includes as a standard feature, a sectioning motor, ensuring fatigue-free ribbon sectioning, and you can select the section thickness at the control panel, outside the cryochamber.

The Leica CM3050 S Cryostat can be easily disinfected with Leica Cryofect disinfectant spray at a temperature of around –20°C. The entire cleaning process is completed within less than 25 minutes.

leica cm3050 s refurbished cryostat research


Precision Sectioning

When working with large samples, accurate specimen orientation and feed are crucial. The precise specimen orientation system with zero position provides for x/y adjustment of up to 8°. The specimen feed system with 25mm horizontal feed allows for reproducible thin sections.






leica cm3050 s refurbished cryostat research

Precision Cooling

An independent refrigeration system for the object head provides for temperature changes and efficient specimen temperature control to adjust for difficult samples such as brain or fatty tissue.

Highly efficient insulating materials and a dedicated cooling system support stable cryochamber temperatures, even when producing serial sections all day long.

Stay Organized

With critical items at hand, you can focus on your sectioning job. Freezing stage and tool tray in a large cryochamber, as well as an easily accessible storage area on top of the cryostat help you staying organized. The motor drive with foot-pedal enables you to have both hands free for sample handling.




Stay Focused

Section thickness totalizer and counter with reset button facilitate target preparation and promote fast trimming between levels. With the reverse section counter, a preselected number of sections can be carried out in both sectioning and trimming mode.

Comfortable Sitting Position

The Leica CM3050 S cryostat with its low working height and available knee space allows the user to work comfortably while sitting.




CM3050 S Downloads


Operator Manual

Cryostat Accessories


Width: 882 mm
Depth: 766 mm
Height: 1040 mm
Weight (incl. microtome): approx. 180 kg
Temperature setting range: 0°C to -40°C
Maximum specimen size: 40 x 55 mm
Cutting speed: 0.1 mm/s to 170 mm/s
0.1 mm/s to 100 mm/s
Vmax: 210 mm/s
Section thickness setting 0.5 to 300 μm
Maximum specimen size 40 mm x 55 mm
Horizontal specimen feed 25 mm
Vertical specimen stroke 59 mm
Specimen retraction 50 pm
Specimen precision orientation by 8° (x/y/z axis)
Trimming 5 to 150 μm ± 0,5 μm in steps of 5, 10, 30, 50, 100 and 150 μm
Motorized coarse feed at two speeds 500 μm/s and 1,000 μm/s
Cutting speed ranges 0.1 mm/s to 170 mm/s, 0.1 mm/s to 100 mm/s, Vmax 210 mm/s
Temperature setting range 0°C to -40°C
Defrosting programmable 1 automatic defrost cycle/24 h duration; from 6 to 12 min; manual defrosting
Freezing shelf temperature Approx. -43°C at an ambient temperature of 22°C
Temperature setting range -10°C to -50°C (+/-3 K)
Dimensions (W x H x D) 882 x 1040 x 766 mm
Weight (including microtome) Approx. 180 kg
Power draw 1800 VA


Additional information




Automatic Cryostats


CM3050 S

Dimensions (W x D x H)

35 x 30 41 in


397 lbs