Histology Educational Series In the previous blog we saw that every histology laboratory has a method for preparing paraffin cell-block specimens, and we reviewed those methods. This review showed that all of these methods display various deficiencies with regard to collecting and preserving the entirety of the patient specimen with optimal retention of all of …
Histology Educational Series Every histology laboratory has a method for preparing paraffin cell-block specimens. Certain cytology specimens, fine needle aspirates (FNAs), tiny tissue fragments, fragmented needle core biopsies and suspensions of cells for both clinical and research evaluation all require a method to get the specimen from the specimen container into a paraffin block for …
Some specimens may be very tiny; on the order of less than 0.1 cm. Some methods employ the use of mesh cassettes, “tea bag” biopsy pouches, sponges, wrapping paper, etc. in order to contain the specimen and prevent it from escaping the tissue processing cassette. A disadvantage of the above methods is that upon embedding, …
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